This paper is a report of a haplotyping process to determine if the patient was a carrier for the breast cancer gene, BRCA2.
Written in 2005; 1,020 words; 3 sources; MLA; $ 36.95
Paper Summary:
This paper explains that haplotype analysis is used to determine if a disease is hereditary and to pinpoint the family members who are carriers for the mutation that causes the disease. The author points out that the pattern of markers associated with marker D aid researchers in identifying whether an individual carries the abnormal form of BRCA2, but there may be many sources of error, including cross-contamination of samples while loading them into the gel, too much voltage causing the products to run too far across the DNA, and general human error. The paper stresses that haplotype testing should be widely available to anyone who wants it because, with this knowledge, the patient may take proactive steps, such as taking Tamoxifen. Charts.
Table of Contents
Introduction
Materials and Methods
Observation and Results
Discussion Questions
Conclusion
Biotechnology-Breast Cancer Detection
From the Paper:
"There are two genes identified with breast cancer. The first is BRCA1. In families that have a history of cancer through multiple generations, women with abnormalities in the BRCA1 gene have a 85% chance of developing breast cancer and a 44% chance of developing ovarian cancer by the age of seventy. Studies of families that were considered high-risk showed that women who had BRCA2 alterations were less likely to develop breast/ovarian cancer than those with BRCA1. Men who inherit an abnormal BRCA2 gene are about 80 times more likely to get breast cancer than a man without the BRCA2 abnormality."
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