Alopecia

Paper Summary:

This paper describes alopecia areata, a systematic hair loss disorder, as a disease that is independent of race, gender or age, hence affected people represent a wide and diverse group. The writer details the effects of the disease which can be either permanent or reversible depending on the nature and extent of damage to the hair follicles. It is believed that both genetic and environmental factors have an influence in the onset of the condition. While there is no complete cure as of yet for alopecia, treatment is primarily aimed at slowing down and containing the severity of the symptoms. This paper also discusses the psychological devastation suffered by the affected person which at times can be debilitating. This paper contains a brief yet concise overview of the various types of alopecia as well as the possible treatment options available.

Table of Contents:
Introduction
Alopecia (Different Types)
Hair Follicles (Complex Morphognesis)
Androgenic Alopecia
Molecular Pathology of AGA
Immunology of Alopecia Areata
Microcirculation in Scalp Tissues
Cosmetic Surgery
Conclusion
Bibliography

From the Paper:

"Research into the pathophysiology of AGA though still inconclusive, has offered enough insight and has identified the important role of androgens in the progressive miniaturization of the hair follicles leading to baldness. Testosterone and its metabolite dihydrotestosterone (DHT) in particular have been directly related as causative factors. The presence of the enzyme 5[Alpha]-reductase is essential for the catalytic reduction of testosterone into the more potent form of DHT. Chromosome 2p has the gene necessary for encoding 5[Alpha]-reductase. Extensive studies conducted on people suffering from AGA have revealed an excess of 5[Alpha]-reductase, and consequently greater amounts of DHT. DHT affects the hair follicles by binding with the dermal papilla cells creating androgen receptor complexes. Androgen receptors act as transcription factors and are directly involved in the synthesis of the protein substances that affect the hair follicles."

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