Infectious Mononucleosis

Paper Summary:

The paper discusses infectious mononucleosis that is caused by the Epstein-Barr virus (EBV) and its associated clinical aspects. The paper examines the etiologic agents, pathogenesis, clinical signs and symptoms, diagnosis and treatment.

Outline:
Introduction
EBV and the Infectious Mononucleosis
Conclusion

From the Paper:

"The Epstein-Barr virus, or EBV, is a double-stranded DNA herpesvirus and is one of the most common human viruses worldwide. In the United States, 95% of adults between 35 to 40 years old have been infected (Centers for Disease Control and Prevention [CDC], 2008). Infants become susceptible to this virus through maternal transmission. Adolescents and young adults may obtain this virus through another person's saliva. EBV is associated with multiple malignancies such as Burkitt's lymphoma, lymphoproliferative disease, Hodgkin's lymphoma, CNS lymphomas in AIDS, and nasopharyngeal carcinoma (Mandell, Bennett, and Dolin, 2005). When adolescents and young adults get infected by EBV, 35% are likely to develop infectious mononucleosis. People who are infected by EBV may not necessarily develop a full-blown disease; majority of the patients who do have this virus have immune systems that are competent enough to control the infection. An interruption of this balance may result in the manifestation of an EBV-associated disease that may develop (Papesch and Watkins, 2001)."

Sample of Sources Used:

• Centers for Disease Control and Prevention. (12 June 2008). Epstein-Barr virus and Infectious Mononucleosis. [Online.] Retrieved 12 June 2008 from the Web site: http://www.cdc.gov/ncidod/diseases/ebv.htm
• Ferri, F. F. (2008). Ferri's Clinical Advisor. PA: Mosby Elsevier.
• Iara, C., Arena, L., di Maio, G., Fracassi, M. G., Leonardi, M. S., Famulari, C., & Cascio, A. (2007). "Acute acalculous cholecystitis during the course of primary Epstein-Barr virus infection: a new case and a review of the literature." International Journal of Infectious Diseases, doi:10.1016/j.ijid.2007.10.005.
• Mandell, G. L., Bennett, J. E., & Dolin, R. (2005). Principles and Practice of Infectious Diseases, 6th ed. PA: Elsevier, Inc.
• Papesch, M., & Watkins, R. (2001). "Epstein-Barr virus infectious mononucleosis." Clinical Otolaryngology, 26: 3-8.

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