A discussion of the function and structure of enediyne antibiotics.
Written in 2009; 840 words; 5 sources; MLA; $ 29.95
Paper Summary:
The paper discusses enediyne antibiotics' potential as an anti-tumor treatment and as an inhibitor of aggressive cancer growth. The paper describes the function and structure of these antibiotics and lists some of the known enediynes and their derivation from microorganisms.
From the Paper:
"Enediyne antibiotics have garnered increasing interest from the fields of chemistry, biology, and chemical sciences because of their great potential as an anti-tumor treatment. It has been said that enediyne antibiotics are 1,000 times more potent than adriamycin, one of the most effective and clinically used antitumor antibiotics (Liu and Shen 382). Enediynes have also been demonstrated to inhibit the growth aggressive cancers such as of cervical carcinoma, leukemia, and melanoma (Shao 50). Enediynes are uniquely characterized by their molecular architectures, mechanism of action, as biological activities. Currently, there are three types of enediyne antibiotics: the calicheamicin-esperamicin type; the dynemicin type, and; the chromoprotoein type. The first group includes the calicheamicins, esperamicins, and nanenamicin. The chromoproteins are neocarzinostatin, kedarcidin, C-1027, and maduroprotein."
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