Enediyne Antibiotics

Paper Summary:

The paper discusses enediyne antibiotics' potential as an anti-tumor treatment and as an inhibitor of aggressive cancer growth. The paper describes the function and structure of these antibiotics and lists some of the known enediynes and their derivation from microorganisms.

From the Paper:

"Enediyne antibiotics have garnered increasing interest from the fields of chemistry, biology, and chemical sciences because of their great potential as an anti-tumor treatment. It has been said that enediyne antibiotics are 1,000 times more potent than adriamycin, one of the most effective and clinically used antitumor antibiotics (Liu and Shen 382). Enediynes have also been demonstrated to inhibit the growth aggressive cancers such as of cervical carcinoma, leukemia, and melanoma (Shao 50). Enediynes are uniquely characterized by their molecular architectures, mechanism of action, as biological activities. Currently, there are three types of enediyne antibiotics: the calicheamicin-esperamicin type; the dynemicin type, and; the chromoprotoein type. The first group includes the calicheamicins, esperamicins, and nanenamicin. The chromoproteins are neocarzinostatin, kedarcidin, C-1027, and maduroprotein."

Sample of Sources Used:

• Gredicak, M. and Jeric, I. "Enediyne compounds - new promises in anticancer therapy." Acta Pharm. 57(2007): 133-150.
• Kovalenko, S. V. and Alabugin, I. V. "Lysine-enediyne conjugates as photochemically triggered DNA double-stranded cleavage agents." Chem Commun doi: 10.1039/b417012a (2005): 1444-1446.
• Liu, W. and Shen, B. "Genes for the production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein." Antimicrobial Agents and Chemotherapy 44.2 (2000): 382-392.
• Prokop, A. et al. "Induction of apoptosis by enediyne antibiotic calicheamicin 911 proceeds through a caspace-mediated mitochondrial amplification loop in an entirely Bax-dependent manner." Oncogene 22(2003): 9107-9120.
• Shao, R. "Pharmacology and therapeutic applications of enediyne antitumor antibiotics." Current Molecular Pharmacology 1(2008): 50-60.

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