A review of the treatment of depression with specific reference to the drug duloxetine, which is available under the trade name of Cymbalta.
Written in 2008; 1,830 words; 8 sources; APA; $ 58.95
Paper Summary:
The paper discusses antidepressants and states that clinical evidences show that the pathophysiology behind depression is due to neurotransmitter abnormalities in the brain. The paper reports that antidepressant medications act by correcting these abnormalities. The paper states that tricyclic antidepressants (TCA) and monoamine oxidase inhibitors (MAOIs) are the oldest type of antidepressants but these have been replaced by the newer serotonin norepinephrine
reuptake inhibitors. Examples of these are venlafaxine and duloxetine. The paper further discusses the activity, side effects and mode of action of duloxetine which is available under the trade name of Cymbalta.
From the Paper:
"Duloxetine hydrochloride, or Cymbalta, is a new antidepressant that possesses this dual action. It is known to have three clinical uses: as an antidepressant, as a pain reliever for diabetic peripheral neuropathies, and for alleviating urinary stress incontinence among women (Bandolier, 2007). It has also been approved for pharmacologic management of generalized anxiety disorder (Food and Drug Administration, 2006). Cymbalta has an advantage over venlafaxine. Cymbalta tends to bind tightly to specific serotonin and norepinephrine receptors than venlafaxine. This mechanism allows Cymbalta to have more specific action and less adverse effects. Moreover, it has been established that Cymbalta is effective in alleviating pain among patients who experience pain along with their depression. Studies have shown that duloxetine attenuates chronic and persistent pain within nociceptive transmission pathways."
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