Toxicology

Paper Summary:

The paper gives an overview of toxicological issues and their effects on health aspects. The paper explains why smokers have a greater risk for manifestation of asbestosis than do non-smokers, the scientific content breakdown of aspirin poisoning, the clear link between a low protein diet and increasing blood levels of cadmium and lead and, lastly, the dangers of alcohol. It explains how the human body is a very delicate piece of machinery with very fine balancing mechanisms and the effects that the toxicological issues mentioned have on it.

From the Paper:

"Aspirin poisoning creates acid base abnormalities in the body and hence monitoring the blood and urinary Ph values are vital during the treatment. It is well known that blood is a well-buffered fluid system in the body and its normal Ph is 7.41. [DEHL] Since aspirin is quickly hydrolyzed into salicylic acid in the blood plasma there is an observed increase in acidity in the plasma. Increasing plasma salicylate levels leads to metabolic acidosis, which is compensated for by respiratory alkalosis resulting in fast deep breathing. The kidney, as an important homeostatic organ of the body, tries to compensate by absorbing h+ ions or HCo3 ions. An increase in urine ph in effect implies that there is an increase in acidity of blood, which the kidney tries to set right. Sometimes, alkaline diuresis maybe necessary to bring down the urinary and blood acidity levels and to facilitate the kidney in increasing the absorption and urinary elimination of salicylates. [eMedicine] Thus, in effect the blood and urinary Ph are vital statistics in the treatment of aspirin poisoning."

Sample of Sources Used:

• State of Connecticut, 'O'Reilly vs. General Dynamics Corporation', Available at, http://wcc.state.ct.us/crb/1997/3339crb.htm Accessed Dec 11th 2005
• Mayo Clinic, 'Asbestosis', Available at, http://www.mayoclinic.com/health/asbestosis/DS00482/DSECTION=7& Accessed Dec 11th 2005
• eMedicine, "Aspirin Poisoning", Available at, http://www.emedicinehealth.com/articles/19788-6.asp Accessed Dec 11th 2005
• DEHL, "The Role of Ph and Healthy Living", Available at, http://www.dehlgroup.com/acidph2.html Accessed Dec 11th 2005
• Medline Plus, 'Zinc in Diet', Available at, http://www.nlm.nih.gov/medlineplus/ency/article/002416.htm Accessed Dec 10th 2005

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