Sickle-Cell Anemia

Paper Summary:

This paper is a case study of a 37-year old African-American male with a diagnosed case of sickle-cell anemia who presents himself to the emergency department with changes in sensorium of two days duration. It examines his symptoms, follows his admission procedure and discusses the virulence factors of sickle-cell anemia.

From the Paper:

"Upon admission, he was stretcher-borne and noted to be unconscious and unresponsive to verbal commands but localized painful stimuli. Vital signs were: HR 104, RR 25, BP 126/78, T 102oF. Physical examination was significant for nuchal rigidity, Brudzinski's and Kernig's sign. A limited neurological examination revealed no papilledema, bilateral hyperreflexia and dorsifexion of the big toe; no localizing signs were noted. A peripheral line was immediately established and a ceftriaxone loading dose was given followed by vancomycin. A non-contrast cranial CT scan revealed a resolving paranasal sinusitis; no mass lesions or midline shifts were noted. "

Sample of Sources Used:

• Di Guilmi, Anne Marie and Andrea Dessen. "New approaches towards the identification of antibiotic and vaccine targets in Streptococcus pneumoniae." EMBO reports. 3 (2002): 728-734. 16 Aug 2006. <http://www.nature.com/embor/journal/v3/n8/pdf/embor106.pdf>
• Todar, Kenneth. Todar's Online Textbook of Bacteriology. Madison, WI: University of Wisconsin-Madison, 2003. 16 Aug 2006. <http://www.textbookofbacteriology.net/>
• Victor, Maurice and Allan H Ropper. Adams and Victor's Principles of Neurology. 7th ed. New York, N.Y.: McGraw-Hill Companies, Inc., 2001.

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