Metabolic Syndrome

Paper Summary:

The paper states that patients with metabolic syndrome have a constellation of conditions that include obesity and disorders of adipose deposition, insulin resistance and independent factors of hepatic, vascular and immunologic origin as well as the influence of aging and hormones. The paper discusses a case study of a woman with metabolic syndrome who wishes to become pregnant. The paper explains the suitability of the drug metformin and her need for weight loss.

From the Paper:

"In the United States, metabolic syndrome will soon become a more significant risk factor for heart disease than cigarette smoking. Elements of insulin resistance and hyperinsulinemia are associated with glucose intolerance and eventual progression to Type 2 diabetes. Associated elements include hypertriglyceridemia, hypertension, polycystic ovary syndrome, hypercoagulability states and vascular inflammation. The cardiovascular system is the primary body system involved in metabolic syndrome. Patients with metabolic syndrome have a constellation of conditions which are defined below."

Sample of Sources Used:

• Reaven G. (2002) Metabolic syndrome. Pathophysiology and implications for management of cardiovascular disease. Circulation.106:286-288
• Manson JE, Willet WC, Stampfer MJ, Colditz GA, Hunter DJ, Hankinson SE, et al. (2005) Body weight and mortality among women. N Eng J Med 333:677-85
• Juahan-Vague I, Alessi MC. (1997) PAI-1, obesity, insulin resistance and risk of cardiovascular events. Thromb Haemost 78:656-60
• Wilson PW. (2004) Estimating cardiovascular disease risk and the metabolic syndrome: a Framingham view. Endocrinol Metab Clin N Am. 33:467-81
• Talbott EO, Guzick DS, Sutton-Tyrrell K, McHugh-Pemu KP, Zborowski JV, Remsberg KE, et al. (2002) Evidence for association between polycystic ovary syndrome and premature carotid atherosclerosis in middle-aged women. Arterioscler Thromb Vasc Biol 30:2414-21

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