A review of the article "In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2" by Vassilev at el.
Written in 2008; 931 words; 1 sources; APA; $ 33.95
Paper Summary:
The paper summarizes the article "In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2" and its study of the MDM2 protein which strongly binds to, and modulates the activity of the p53 tumor suppressor protein. The paper describes the methods and testing used and posits that the methods were relative to the objective and were properly carried out. The paper therefore agrees with the conclusion reached by the article and concludes that this is indeed a promising treatment should it be proven that suppression of MDM2 activity in p53 proteins may lead to the reduction of tumors in humans and animals.
Outline:
Summary
Method
From the Paper:
"The main focus of the article is around the MDM2 protein which strongly binds to, and modulates the activity of the p53 tumour suppressor protein by an autoregulatory feedback loop. This is done through three mechanisms. Firstly, MDM2 binds at the p53 transactivation site and blocks its activation of transcription initiation. Secondly, it participates in the nuclear export of p53. Thirdly, it serves as a ubiquitin ligase, promoting the degradation of p53. When p53 is activated, it can bring a halt upon the cell cycle and cause apoptosis."
We have thousands of high-quality term papers, research papers, essays, book reports and dissertations on every topic. At AcaDemon, you can download those term papers to help you write yours! You can be sure that the term paper, essay, book report or research paper you download are top-quality, competitively priced and high-level work.
This Free Term Paper Abstract is a part of our Term Paper Library.Here you can purchase research papers, examples of essays, academic dissertations, articles, notes, analytical papers, book reports, stories and poems. We have thousands of persuasive, point-of-view, narrative, critical, compare and contrast and other types of essays in our Library. You can also find here Term papers on "The p53 Tumor Suppressor Protein", Essays on "The p53 Tumor Suppressor Protein", Research papers on "The p53 Tumor Suppressor Protein", Student papers on "The p53 Tumor Suppressor Protein", Book reports on "The p53 Tumor Suppressor Protein", Dissertation on "The p53 Tumor Suppressor Protein", Thesis on "The p53 Tumor Suppressor Protein", Summary of paper on "The p53 Tumor Suppressor Protein", Articles written on "The p53 Tumor Suppressor Protein".
Look for more research papers, essays and book reports on