GSTs, Smoking, and Lung Cancer

Article Review # 116670

Medical and Health > Medical Studies
Medical and Health > Public Health Issues

A review of three articles on studies that examine the relationship between smoking and lung cancer through enzyme interactions.

4,832 words () | 3 sources | MLA | 2009 United States

Paper Summary:

This paper first examines an article that aims to determine the exact relationship between carcinogens and GSTs, and how the risk of lung cancer may be associated with genetic variations of metabolic enzymes such as GSTs. The paper describes the procedural steps to the experiment and then discusses the results of the experiment, which imply that metabolic enzymes are not disrupted by carcinogenic materials introduced to the body through cigarette smoking. The paper then discusses an article that specifically explores the effects of environmental or second hand smoke to non smokers. Finally, the paper examines a case study involving the relation of GSTM1 Polymorphism and smoking in a French population.

From the Paper:

There are many tobacco carcinogens that have been proven to be activated through metabolizing enzymes. These enzymes, although universally present within our bodies do not have a set presence within our body. Genetic variation tied with S-transferases classes have been well documented and thus the purpose of this study will be to see what the exact relationship carcinogens have with the GSTs and how the risk of lung cancer may be associated with genetic variation of metabolic enzymes such as GSTs. Although many studies have been made on the link between GST polymorphism and lung cancer, few have had a comprehensive look at the demographic distribution of lung cancer. Separately published reports show that lung cancer risks are proportionally higher among Asians because they have squamous cell and small cell carcinomas.

Sample of Sources Used:

http://carcin.oxfordjournals.org/cgi/reprint/23/8/1343 and click begin manual download.
http://bmj.bmjjournals.com/cgi/content/full/315/7114/980?view=full&pmid=9365295
http://ije.oxfordjournals.org/cgi/reprint/28/5/829.pdf

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APA Citation:

GSTs, Smoking, and Lung Cancer (2012, January 15). Retrieved February 09, 2012, from http://www.academon.com/Article-Review-GSTs-Smoking-and-Lung-Cancer/116670