C-Reactive Protein

Paper Summary:

In this essay, the writer notes that Dandona's article entitled 'Effects of Antidiabetic and Antihyperlipidemic Agents on C-Reactive Protein', centers on type 2 diabetes mellitus (DM) and the increased risk of cardiovascular disease. The writer discusses that insulin resistance in type 2 DM predisposes patients to develop cardiovascular disease, and has the associated risk factors for atherosclerosis, a chronic inflammatory disease of the arteries. The writer notes that higher CRP concentrations are found in patients with type 2 DM and Dandona theorizes that reducing these concentrations could have clinical benefit. As glucose and lipid levels are also often elevated in type 2 DM patients, an agent that affects all three of these would be beneficial to patients. The writer maintains that Dandona's article is a retrospective exploration of literature on antidiabetic and antihyperlipidemic agents which reduce these factors.

Outline:
Abstract

From the Paper:

"The complex metabolic disorder that is type 2 DM is characterized by chronic hyperglycemia. In addition, due to the patient's insulin resistance, due to impaired insulation secretion and/or insulin action, there is also disturbances in lipid, carbohydrate and protein metabolism. This predisposes the patient to the development of cardiovascular disease, due to the proinflammatory and hypercoagulable state. As Dandona notes, an elevated CRP concentration is a predictor of cardiovascular events, in fact, it is a far better indicator than low-density lipoprotein cholesterol (LDL-C) even amongst healthy people. Although previous research indicates that CRP does not initiate atherosclerosis, but instead progresses the disease, the fact that CRP inhibits nitric oxide production suggests that it also has a role in the initiation of atherosclerosis as well."

Sample of Sources Used:

• Dandona, P. (Mar 2008). Effects of antidiabetic and antihyperlipidemic agents on C-Reactive protein. Mayo Clinic Proceedings, 83(3), pp. 333-342.

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