Paper Summary:

In this article, the writer discusses the use of gene therapy to cure the inherited disorder of sickle cell disease. The writer focuses on the biochemistry of this treatment process. Further, the writer gives a review of sickle cell disease.

From the Paper:

"Knowledge of a disease heralded by painful episodes of substantial intensity which in many instances leads to early death has existed in Africa for over a century. Stuart and Nagel pointed out that James Herrick a physician who was also a Chaucer scholar first identified sickle cells in a medical student from Grenada. In the first half of the twentieth century Linus Pauling showed the abnormal electrophoretic mobility of hemoglobin in an affected individual. Vernon Ingram discovered that the defect of ..."

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