Abstract This paper explores the working hypothesis that caloric restriction may prevent Alzheimer's disease. In addition, the paper explores the idea that individuals with the ApoE genotype and a higher intake of calories have a higher risk of AD than those who do not carry the apoE4 allele.
From the Paper "Alzheimer's Disease is a form of dementia that is marked by the loss of mental ability and various cognitive functions. The disease usually occurs in old age and is not detectable at birth. (Robinson) There is no consensus on the cause of AD but researchers have found a genetic link in the development of the disorder. The Gale Encyclopedia of Medicine explains that there are various genes that are implicated in AD. One such gene is amyloid precursor protein (APP), which creates amlyloid. When there are mutations in this gene the result is often the early onset of Alzheimer's disease. It is also reported that most individuals that have Down syndrome also develop AD."
Abstract As more and more people live longer, many suffer from senility and Alzheimer's disease. This paper discusses the stages of the disease and how medical science has advanced in its ability to diagnose Alzheimer's.
The paper also examines the future for this disease.
Introduction
The Definition of Alzheimer's Disease
The Genetics of Alzheimer's Disease
Stages of Alzheimer's Disease
Advances in Diagnosing Alzheimer's Disease
Predicting Alzheimer's Disease
Outlook for the Future
Footnotes
Bibliography
From the Paper "Other researchers are focusing on the 'oxidative stress' and 'programmed cell death' parts of the puzzle. It is becoming clear that oxidative stress occurs in AD, but it is not yet clear whether oxidation actually causes the neuro-degeneration, or is simply another side effect of AD. Some scientists believe that oxidative stress is a relatively early event in the disease process. They argue that the aging brain is less able to defend itself against oxidative stress, and that this helps to explain why AD is a disease that primarily strikes older people. Researchers are working now to understand whether beta-amyloid initiates the oxidative damage in AD. Vitamin E and some of the other drugs that show promise against AD may have anti-oxidant properties."
Abstract In this article, the writer looks at the molecular biology of the cholesterol transport from arterial walls to the liver for biliary excretion. The paper looks at all the genes and their agonists and antagonists involved - LXR, PPAR, ABCA1, apoE, oxysterols, cholesterol metabolites etc. The writer then discusses how they all work together to transport cholesterol from the arterial walls in order to minimize atherosclerosis.
From the Paper "Atherosclerosis is a form of arteriosclerosis in which plaque builds up in the inner linings of the arteries. Plaque consists of a combination of fatty substances, cholesterol waste products from cells fibrin and calcium and usually develops in medium and large arteries, thickening their walls and causing them to lose elasticity and so become less resilient. Atheromatous plaques build up in vessel walls and in advanced stages reduce or restrict blood flow through the vessel lumen. The inner covering of the atheroma may ... "
